Pengaruh Stress Secara Molekuler Terhadap Terjadinya Oral Candidiasis

Abstract

Introduction. Mental stress is a predisposition factor in the development of oral candidiasis. The central nervous system will respons to mental stressby transmite a signal stress to HPA axis. Further more hypotalamus will than produces carticosteroid hormon (CKH)which leads to the activation of pitutarygland to release ACTH. Furthermore ACTH will induce the release of glucokarticoid,which will be than reduce the body defence mechanism and inflamation by preventing antigen presentation performed by macropag, lympocite proliferation as well as lympocite diifferentation to become efector cells such as Tn, TC, NK, cellβ.Glucosteroid it self willl promotes the increement of local IL. 1β, IL .6, IL. 8 in the gingival crevice and leading to the reduction of sig A, Ig G and neutrophil fuctions.Oral candidiasis is an opportunity infection caused by the over development of C Albican. Altgough in normal condation C albian is a normal and flora of the mouth. How ever it can be turned in to patogenic when human body diffence is lower.Aim of the study. The aimof this study is to discuss in a molecular approachany possible imune cell that is affected by mental stress condition,which also induces the C.Albican to become pathogenic. Discussion. C. albicanis a normal flora of the mouths. It can change into pathogenic due to the occurance of mental stress, which induces the reduction of human body deffence, and cause the reduction of Sig A, Ig G. This Sig A have the ability to prevent C. Albican adhesivenes in oral mucouse cells. The main couse of oral infection is the adhesiveness of microbacteria into the mucouse cells. The reduction of sig A will provide an opportunity to the adhesivityness disturbances. The function of Ce T is to destroy pathogenic cell and to actified B cell as well as other imune cells.Mental stress will provide a high chance to the development of oral candidiasis, and further more the candidiasis can spread wider to other organ, as T and β cells reducetheir function in destroying pathogenic cells.Conclusion. The realtionship mechanism of stress and the development of oral candidiasis can be used as refference in the management chronic deseases especially in the case of oral candidiasis.