The Role of Type 17 Helper T Cells and Regulator T Cells in Human Immunodeficiency Virus (HIV) Infection: A Review

Abstract

The Human Immunodeficiency Virus (HIV) continues to be a major global health issue, affecting millions of individuals globally, in developing countries, specifically. HIV infection is indicated by the complex interactions between the virus and the host immune system. Among the various immune cell subsets involved, T regulatory cells (Tregs) and T helper 17 cells (Th17) play pivotal roles in preserving immunological homeostasis. This review provides a comprehensive overview of the current understanding of Treg and Th17 cell activities during HIV infection, exploring their complex interactions, how they affect immune dysregulation and disease progression, and possible therapeutic implications.