Confirmatory Factor Analysis Immune Response (TNF-α) to Dust Exposure on Tulungagung Marble Craftsmen

Abstract

Background: As marble craftsmen, marble dust which may contain high levels of silica potentially exposed to the job, so workers have a risk of danger and can cause health problems. The purpose of this study is to determine the immune response of workers in order to identify complaints of respiratory disorders, measure the condition of workers' lung function, specifically FEV1 using an autospirometer, and measure levels of TNF-α. Objective: This study aims to build a model of the immunological response (TNF-α) to dust exposure using CFA (confirmatory factor analysis) and route analysis (Path Analysis). Materials and Methods: This type of study used a cross-sectional, observational methodology. This study focuses on all 26 marble craftsmen in the marble house industry in the Tulungagung area. Dust levels were sampled using a type 500 high volume dust sampler for 10 minutes at each measurement location as one of the factors examined. TNF-α levels were extracted from blood serum samples and tested using the ELISA technique. Lung function was examined using a spirometer, and respiratory symptoms were assessed using an interview questionnaire. Results: According to the findings of the path analysis test, the immunological response is influenced by the following variables: 1) the characteristic has a T statistic value of 2.750, which is more than 1.96. 2) The T statistic for dust exposure is 2.155, which is more than 1.96. The T statistic score of 3.102 for smoking habit is larger than 1.96.