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    SINTESIS 1-(4-TRIFLUOROMETILBENZOILOKSIMETIL)-5FLUOROURASIL SEBAGAI UPAYA PENGEMBANGAN OBAT ANTIKANKER

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    Nita Ernawati (092210101097)_1.pdf (186.0Kb)
    Date
    2013-12-17
    Author
    Nita Ernawati
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    Abstract
    ABSTRACT 5-fluorouracil is an antimetabolite class of anticancer agents that work induces apoptosis by inhibiting thymidilic acid biosynthesis. A novel 5-fluorouracil derivatives, 1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil were synthesized by two steps reaction. The first step is alkylation reaction between 5-fluorouracil, formaldehyde and aquadest to produce 1-hidroxymethyl-5-fluorouracil. The second step is benzoylation reaction between 1-hidroxymethyl-5-fluorouracil and 4trifluoromethylbenzoylchloride for 11 hours to produce the target compound. Target compound purified by column chromatography. Purified compound characterized and identified by 1 HNMR and FTIR KBr. Product compound form white needles crystal with melting range 172-174 o C. Spectra of 1 HNMR and FTIR KBr showed that pure 1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil was successfully synthesized.
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    http://repository.unej.ac.id/handle/123456789/9323
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    UPA-TIK Copyright © 2024  Library University of Jember
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    Indonesia DSpace Group :

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