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    SINTESIS 1-(4-METOKSIBENZOILOKSIMETIL)-5-FLUOROURASIL SEBAGAI UPAYA PENGEMBANGAN OBAT ANTIKANKER

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    Ifada - 082210101047_01.pdf (671.2Kb)
    Date
    2013-12-03
    Author
    Ifada
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    Abstract
    A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4- methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5- fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4- methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4- methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid.
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    http://repository.unej.ac.id/handle/123456789/2700
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    UPT-Teknologi Informasi dan Komunikasi copyright © 2021  Perpustakaan Universitas Jember
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    Indonesia DSpace Group :

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