| dc.description.abstract | Context: Epidemiological and microbiological studies have reported association
between periodontitis and coronary artery disease (CAD), experimental study that
simulated cause–effect of periodontitis in CAD, however, was lacking. Aims: This
study aimed to demonstrate the occurrence of coronary artery disease as a
consequence of induced periodontitis in a rat model. Settings and Design: This in
vivo experimental study using the post test only control group design. Methods and
Material: A total of 12 rats (Rattus norvegicus) were divided into control and
periodontitis groups (six rats in each group). Periodontitis was induced by injection
of periodontitis bacteria Porphyromonas gingivalis in buccal gingival sulcus of left
mandibular teeth, thrice a week for 4 wk. All rats were fed with normocholesterol
diet. At the end of study, all rats were sacrificed. The rats’heart containing coronary
arteries were removed, cut cross-sectionally and prepared for histochemistry assay.
Statistical analysis used: Descriptive analysis was used to assess the frequency of
CAD lesion, and t test for IMT Results: All of rats in periodontitis group
demonstrated signs of CAD. Coronary artery local inflammation indicated by
leukocytes and erythrocyte accumulation were identified in all rats in periodontitis
group (100 %). Parameters of intimal collagen disintegration and endotelial
disintegration were also commonly occured (91.66 % each), atheroma (41.66 %),
stenosis (41.66 %). Periodontis group demonstrated significantly higher mean IMT
(p < 0.05) compared to control group, 3.6 µm ± 1.4 µm and 2.1 µm ± 0.7 µm,
respectively. Conclusions: Periodontitis induced CAD. Periodontitis rat model
might be used to represent as atherosclerotic model as well. | en_US |
