| dc.contributor.author | SUSILAWATI, I Dewa Ayu | |
| dc.contributor.author | SURYONO, Suryono | |
| dc.contributor.author | PURWANTO, Purwanto | |
| dc.contributor.author | BURLAKOVS, Juris | |
| dc.contributor.author | YARO, Abubakar | |
| dc.date.accessioned | 2020-07-21T04:29:45Z | |
| dc.date.available | 2020-07-21T04:29:45Z | |
| dc.date.issued | 2020-04-21 | |
| dc.identifier.uri | http://repository.unej.ac.id/handle/123456789/99858 | |
| dc.description.abstract | This study aimed to determine whether coffee consumption affects the structure of coronary arterial wall and protects against coronary artery disease
(CAD) in atherosclerotic rat model induced by periodontitis. Rats (n=21) were divided into three groups (i) Coffee group (periodontitis + coffee), (ii) Periodontitis
group
(no
coffee),
and
(iii)
Control
group
(no
periodontitis,
no
coffee).
A
single
dose
of
coffee
suspension
(representing
one
cup)
was
given
daily
by
stomach
sondation
to
the
rats
in
the
coffee
group.
The
experiment
was
conducted
for
5
wk.
At
the
completion
of
the
experiment,
all
of
rats
were
sacrificed.
Their
hearts
containing
coronary
arteries
were
removed
and
analyzed
by
histochemistry
assay.
In
addition,
the
serum
level
of
collagen
degrading
enzymes
matrix
metalloproteinase–2
(MMP–2)
was
also
analyzed
using
Enzyme–link
immunosorbent
assay
(Elisa).
Results
demonstrated
that
coronary
atherosclerotic
lesions
including
atheroma,
stenosis,
and
vascular
occlusion
were
rarely
identified
in
the
coffee
group.
The
coronary
arterial
wall
demonstrated
relatively
symmetrical
intima-media
thickness
(IMT)
and
the
lumen
diameter
remained
adequate
for
blood
flow.
The
intimal
collagen
was
intact,
dense
and
thick.
MMP–2
level
was
significantly
lower
(P<
0.05)
in
the
coffee
group.
In
conclusion,
coffee
maintained
the
structure
of
coronary
arterial
wall
particularly
the
intimal
collagen,
providing
protection
against
CAD.
This
might
also
mediate
the
vascular
resistance
against
rupture
and
thrombosis
that
might
precipitate
the occurrence
of acute
coronary
syndrome
(ACS). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Coffee Science, Lavras, Vol. 15 (2020) | en_US |
| dc.subject | Acute coronary syndrome (ACS) | en_US |
| dc.subject | Coronary artery disease (CAD) | en_US |
| dc.subject | Histochemistry | en_US |
| dc.subject | Intima-media thickness (IMT) | en_US |
| dc.subject | Matrix metalloproinase-2 (MMP-2) | en_US |
| dc.title | Coffee Protects Cardiovascular Health by Maintaining the Structure of Coronary Arterial Wall Intimal Collagen | en_US |
| dc.type | Article | en_US |
| dc.identifier.kodeprodi | KODEPRODI2010101#Pendidikan Dokter | |
| dc.identifier.kodeprodi | KODEPRODI1610101#Kedokteran Gigi | |
| dc.identifier.nidn | NIDN003096112 | |
| dc.identifier.nidn | NIDN0011106913 | |
| dc.identifier.nidn | NIDN0024105701 | |
