| dc.description.abstract | Background: Trauma-induced ulcers constitute one of the painful abnormalities affecting the oral cavity about which numerous
individuals complain. The prevalence of traumatic ulcers (15-30% of cases) is relatively high compared to other oral lesions.
Unfortunately, the use of anti-inflammatory drugs classified as steroids can lead to contraindications and serious side effects. Hence,
the use of natural ingredients represents an alternative treatment. One such ingredient is red pomegranate containing bioactive
elements acting as anti-inflammatory, antibacterial, antimicrobial, and antioxidant agents which accelerate the healing process in
traumatic ulcers. Purpose: The aim of this study was to determine the effects of the topical application of red pomegranate (Punica
granatum Linn) extract on the healing process in traumatic ulcers in Wistar rats. Methods: 24 male rats, aged 2-3 months, were divided
into six groups, namely; two control groups (PC: triamcinolone acetonide and NC: sterile aquades) and four treatment groups (red
pomegranate extract gel at respective concentrations of 12.5%, 25%, 50% and 75%). A traumatic ulcer was subsequently created using
a flame-shaped burnisher tip 2mm in diameter and heated for ±15 seconds. The diameter traumatic ulcer of each research subject was
measured and observed until it healed within the remedial parameters determined by means of a UNC-15 periodontal probe which
had been placed on it. The data obtained was analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: Topically applied
red pomegranate extract gel can reduce the width of the ulcerated area, while also accelerating traumatic ulcer healing. There was
a significant difference in the healing time between the group using red pomegranate extract gel at a concentration of 75% and the
positive control group using 0.1% triamcinolone acetonide with p=0.44 (p<0.05). Conclusion: Red pomegranate extract gel possesses
the ability to accelerate the healing process in traumatic ulcers. The most effective concentration of red pomegranate extract gel at
accelerating the healing process in traumatic ulcers is 75%. | en_US |
