| dc.description.abstract | The granules of sugar apple seeds extract (Annona
squamosa L.) have been taken as the natural larvacide an economical in
eradicating mosquito flicks of Aedes aegypti L. because of its the content
of toxic compounds such as acetogenin, alkaloids, and flavonoids. In its
use it is feared to cause toxic in the environment, especially the class of
mammals as non-target animals, especially kidney organ. The kidney is an
organ that is susceptible to toxic effects, since it receives 25-30% of the
blood circulation to be cleaned, so that as a filtration organ there is a
possibility of pathological changes. This study aims to determine the effect
granules of sugar apple seeds extract (Annona squamosa L.) on the
histology of white rat (Rattus norvegicus B.). Kidney histology observed as
fat degeneration, hydrophic degeneration, and necrosis of tubular cells
occurred in one field of view. The concentration given was 1 mg, 2 mg, 4
mg, and 8 mg while the negative control induced 2 ml aquades and
positive control using abate 100 mg for 14 days with sonde method. The
analysis used in this research is descriptive analysis with scoring. The
results showed that granules of sugar apple seeds extract did not give
effect to histology of white rat (Rattus norvegicus B.). | en_US |
