| dc.description.abstract | Objectives: In this study, we aimed to investigate the effects
of oral administration of Myrmeleon formicarius
(antlion) extract on liver and kidney histology in
streptozotocin-induced diabetic mice.
Methods: Twenty-four mice received a single intraperitoneal
injection of streptozotocin and were then divided
into six groups. Untreated diabetic mice served as the
negative control group, and glibenclamide-treated mice
served as the positive control group. Mice in the other
four groups, namely T1, T2, T3, and T4 groups, received
M. formicarius (antlion) extract at 2.5, 5, 7.5, and 10 mg/
kg, respectively. Permanent thin sections were used to
examine liver and kidney histology.
Results: The most appropriate antihyperglycaemic
dosage of the M. formicarius extract was 10 mg/kg for 2
days. Histological examination of the liver and kidneys
showed that the antlion extract at 10 and 5 mg/kg
exhibited significant tissue-repair effects.
Conclusion: M. formicarius (antlion) extract can not only
reduce blood glucose levels but also repair
hyperglycaemia-induced tissue damage. | en_US |
