| dc.description.abstract | Neuropathic pain resulted from injury to nerves is often resistant to current treatments and can seriously
cause chronic pain if no appropriate treatment is given. This study was designed to prove the effectiveness
of gabapentin and baclofen in increasing latency time toward thermal stimulus and recovering the
morphology of dorsal horn of spinal cord in neuropathic-induced chronic pain. Forty mice were divided
into 8 groups i.e sham, negative control, gabapentin at three different doses (10, 30, 100 nmol) and
baclofen at three different doses (1, 10, 30 nmol). Neuropathic condition was induced by ligation of sciatic
nerve with Partial Sciatic Nerve Ligation (PSNL) method. Gabapentin and baclofen were administrated
intrathecally once a day for seven days, a week after neuropathic induction. Latency time toward thermal
stimulus was measured on days 0, 1, 3, 5, 7, 8, 10, 12 and 14 after induction. Histology of the dorsal horn
of spinal cord tissue was examined by haematoxylline-eosin staining. The results showed that intrathecal
injection of gabapentin and baclofen significantly increased latency time of mice toward thermal stimulus
compared with negative control. Gabapentin and baclofen are effective as treatment for neuropathic
pain. They can also help the recovery process of the histology in dorsal horn in neuropathic pain. | en_US |
