SINTESIS 1-(4-NITROBENZOILOKSIMETIL)-5- FLUOROURASIL SEBAGAI PENGEMBANGAN OBAT KANKER

Abstract

ABSTRAK 1-(4-nitrobenzoiloxymethyl)-5-fluorouracil were synthesized from a lead compound 5-fluorouracil (5FU), an anticancer commonly used for treating breast cancer. The compound were synthesized by two steps, the substitution of hydroxymethyl to N1 position of 5-FU followed by esterification by 4- nytrobenzoilcloride. The product were purified by coloumn chromatography and identified by 1HNMR and FTIR-KBr. The purity was characterized by TLCDensitometry and its melting point range. Finally, the compound was synthesized successfully.