| dc.description.abstract | Introduction: Diabetic wounds or ulcers happened in Indonesia’s hospitalized diabetes
patients range from 17.3 to 32.9%. The high cost of treatment, the high risk of amputation
and the difficulty of handling diabetic wounds, make it necessary to look for alternative
medicine derived from plants e.g. Merremia mammosa (Mm). This study aimed to analyze
the potential dose of the water fraction of Mm (Lour.) extract on diabetic wound healing
enhancement. Method: This study used fifty -seven male wistar rats that were made
diabetic by intraperitoneal injection of 40 mg/kg body weight streptozotocin. Rats divided
into six groups equally, which consist of positive control (gentamicin 0.1%), negative control
(aquadest) and water fraction of Mm (Lour.) extract dose 12.5 mg, 25 mg, 50 mg and 100
mg. Wound was made by Morton method and treatment applied on the wound every other
day for 21 days. Wound healing process were observed by percent wound healing and
histopathological changings on day 0, 3, 10 and 25, representing each healing phase.
Results: The percentage of reduction in wound size comparison at day 10 showed no
significant different when compared with positive control started from dose 50 mg. This
result is consistent with the histopathological changings parameter (angiogenesis,
macrophage, fibroblast and collagen density). Conclusion: Water fraction of Mm (Lour.)
extract was dose-dependently enhanced the process of wound healing in diabetic rat model
and the most effective dose was 100 mg, which looks similar with positive control. Therefore,
it is potential to be developed further as a topical drug. | en_US |
