| dc.contributor.author | Nurahmanto, Dwi | |
| dc.contributor.author | Sabrina, Friska Wira | |
| dc.contributor.author | Ameliana, Lidya | |
| dc.date.accessioned | 2018-02-13T03:24:22Z | |
| dc.date.available | 2018-02-13T03:24:22Z | |
| dc.date.issued | 2018-02-13 | |
| dc.identifier.issn | 2443-115X | |
| dc.identifier.uri | http://repository.unej.ac.id/handle/123456789/84301 | |
| dc.description | JURNAL ILMIAH MANUNTUNG, 3(2), 197-206, 2017 | en_US |
| dc.description.abstract | Piroxicam, a non steroidal anti inflammatory drugs (NSAID), is an oxicam derivative
which can be used for treatment of various rheumatic diseases, such as rheumatoid arthritis and
osteoarthritis. Piroxicam patch is an affective approach evading piroxicam’s side effect such as
peptic ulcer and first pass metabolism. One of the patch components is polymer that the
function is to control the speed of drug release from the patch. The aims of this study were to
determine the optimum formula of a combination of polyvinylpyrolidone (PVP) and Carbopol to
% moisture content (MC) and the flux release in solid dispersion piroxicam patch using Simplex
Lattice Design. Piroxicam was prepared in the form of a solid dispersion in PEG 4000 to
increase its solubility. The design formula of solid dispersion piroxicam patch made with the
ratio PVP : Carbopol, that were 1 : 0; 0.5 : 0.5; 0 : 1. The optimum formula was chosen with
the ratio PVP : Carbopol, 1: 0, which gave the best result of % MC and flux release. The result
of % MC was 6.91% and the result of flux release was 35.543 µg/cm2
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| dc.language.iso | id | en_US |
| dc.subject | solid dispersion piroxicam patch | en_US |
| dc.subject | PVP | en_US |
| dc.subject | Carbopol | en_US |
| dc.title | OPTIMASI POLIVINILPIROLIDON DAN CARBOPOL PADA SEDIAAN PATCH DISPERSI PADAT PIROKSIKAM | en_US |
| dc.type | Article | en_US |
