| dc.description.abstract | Dry socket is ones of common extraction complication wound healing
in diabetic patient. Metformin administration as blood glucose control theraphy that often
used to prevent this complication, but 20% of patients which consumes have experienced
gantrointestinal side-effect. Recently there is increasing development of alternative
therapies with low side effect to anti-diabetic herbal, such as black seed (Nigella sativa
Linn) which contains thymoquinone. Purpose. The aim of this study is to known the effect of
thymoquinone extract of black seed (Nigella sativa Linn) to blood glucose Level and post
extraction healing in diabetic-induced rats by Steptozotocin. Methods. This study was the
post-test only with control group design. 27 diabetic rats were divided to 3 (three) groups
as follow: group P1 thymoquinone treated , P2 (positive control) treated with metformin,
and K (negative control) treated with aquadest. Each group consist of 9(nine) rats which
were divided into three subgroups based on the observation day, (day 3, 7 and day 10 postextraction).
Diabetic induction was used streptozotocin (STZ) 50 mg/kg. Rats with blood
glucose level ≥ 250 mg / dl was considered as diabetic. Results. There was a significant
difference (p<0.05) between groups P1 to P2, and P1 to K group at day 10 post-extraction.
Conclusion. Thymoquinone may decrease blood glucose level and accelerate the
processing of socket wound healing and considered better than metformin, thus the further
research is need with longer time to understand the effect of thymoquinone in the socket
bone formation process post extraction in diabetic condition. | en_US |
