| dc.description.abstract | To analize the effects of caffeine on improvement osteoclastogenesis
and orthodontic tooth movement. Material and methods: The research method was
experimental laboratories, 16 rats were divided into 2 groups. Group C: the rats were
applied with Orthodontic Mechanical Force (OMF) and 2 ml of distilled water, group T:
OMF and caffeine of 1,37mg/100g BW in 2 ml of distilled water. OMF was conducted by
applying ligature wires in diameter of 0.20 mm on the molar-1 (M-1) of right maxilla and
both incisivus of maxilla. Subsequently, the M-1 of right maxilla was moved to mesial using
Tension Gauce to generate power of 10g/cm2 with Ni-Ti orthodontic closed coil spring.
Histological examination was conducted to calculate the number of osteoclasts. Increased
tooth movement in the rats was measured by measuring from the tip of the distal of M-2 to
the end of M-1 mesial of right maxilla lessened by mesiodistal width of right upper M-1 and
M-2 using digital caliper.Results: the administration of caffeine steeping proved to
effectively increased the number of osteoclast in both compression area and tension area
more than those which were not administered with caffeine (p <0.05). The number of
osteoclast in compression area more than the tension area (p <0.05).The administration of
caffeine improved the movement of M1 of right maxilla compared to those not
administered with caffeine (p <0.05). Conclusion: the administration of caffeine increased
osteoclastogenesis and improved the movement of the teeth, therefore it may be an
alternative to accelerate orthodontic treatment | en_US |
