| dc.description.abstract | Orthodontic treatment is often contraindicated in chronic diabetic condition,
because of its manifestations on periodontal tissues will influence the success of the
treatment. Diabetes is a metabolic disorder which increased from year to year. This
disease characterized by persistenly raised blood glucose levels (hyperglicemia),
resulting from deficiencies in insulin secretion, insulin action, or both. Diabetes can
affect orthodontic tooth movement through several mechanisms. Hyperglycemia in
diabetes will induce the polyol pathway, the production of advanced glycation end
products (AGEs), reactive oxygen species (ROS), and the activation of protein kinase C
(PKC), which will affect the orthodontic tooth movement. By studying the mechanisms
of diabetes on orthodontic tooth movement, it will be useful to determine the
management of orthodontic treatment for patients with diabetes and predict the
complications that might occur. | en_US |
