IDENTIFIKASI DEOKSIPIRIDINOLIN PADA SALIVA WANITA USIA PERIMENOPAUSE

Abstract

Perimenopause is trantition phase of nomal ovulation cicle to menopause that signed decreasing estrogen hormone production. In this phase, women will be physiology and psychology alteration related fluctuation of estrogen hormone. The estrogen level alteration is one of cause reducing of bone density in perimenopause women. When estrogen level decreases, it will induce osteoclast activity and finally cause bone resorption. In bone resorption osteoclast secretes protease that can dissolve collagen which is in organic matrix and free bone mineral. Mature collagen is bound by pyridinium crosslink that it will be degraded in bone resorption process, such as deoxypyridinoline. Deoxypyridinoline have suggested as collagen degradtion marker of bone resorption in serum and urine. This study was objective to identify deoxypyridinoline in saliva of perimenopause women. The subjects of this study were perimenopause women who were 40-55 years old. The subjects had to fulfill informed consent and be undergone intra oral examination, including caries and periodontal index index. After that the subjects collected their whole saliva. Deoxypyridinoline in saliva was identified by Liquid chromatography Mass Spectroscopy. The result showed that deoxypyridinoline level of perimenopause women was about 23.802 ppm. This level was higher than productive women. The conclusion was deoxypyridinoline level in saliva of permenopause women.