| dc.description.abstract | Diabetes is a metabolic disorder characterized by high blood glucose levels or hyperglycemia. Diabetes
can cause damage to multiple organs, such as the heart, eyes, kidneys, nerves, and vascular system, as well as an
increased in periodontal disease. The periodontal disease mechanisms in diabetic conditions including, an increased
of alveolar bone resorption, osteoclast formation, and osteoblast apoptosis. The activity of alveolar bone resorption
were initiated by osteoblast which was secreted a key mediator of osteoclastogenesis process, namely the receptor
activator of nuclear factorκB
ligand
(RANKL).
This article
will
be
discuss
about
the
role
of RANKL
in
the
alveolar
bone
resorption
process
in
diabetes
conditions,
which
would
be
usefull
for studying
the
diabetes
complication
such
as
alveolar
bone
resorption
through
the
mechanism
that
related
with
the
role
of
RANKL. | en_US |
