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    VOLUNTARY EXERCISE UNDER A FOOD RESTRICTION CONDITION DECREASES BLOOD BRANCHED-CHAIN AMINO ACID LEVELS, IN ADDITION TO IMPROVEMENT OF GLUCOSE AND LIPID METABOLISM, IN DB MICE, ANIMAL MODEL OF TYPE 2 DIABETES

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    Environmental.pdf (1002.Kb)
    Date
    2016-06-07
    Author
    Marchianti, Ancah Caesarina Novi
    Arimura, Emi
    Ushikai, Miharu
    Horiuchi, Masahisa
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    Abstract
    Objectuives : Exercise is effective for preventing the onset and development of type 2 diabetes mellitus (T2DM) in human cases; however, the effect of exercise on the pathophysiology using animal models of T2DM has not been fully evaluated, Methods : We applied voluntary exercise under pair-fed (P) conditions in db mice, an animal model of T2DM. Exercising (Ex) and sedntary (Se) mice were placed in a cage, wquipped with a free or locked running wheel, for 4 weeks, respectively. The amount of food consumed by ad libitum-fed wild-type mice under the Se condition (ad-WT) was supplied to all mice, except ad libitum db mice (ad-db). Blood parameters and expression of the genes involved in nutrient metabolism were analyzed. Results: PEx-db (pair-fed and exercising) mice showed significantly lower HbA1c, body weight and liver weight than PSe-db and ad-db mice.
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    http://repository.unej.ac.id/handle/123456789/74527
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    • LSP-Article In Journal [149]

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    Indonesia DSpace Group :

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