Peningkatan Kompaktibilitas Parasetamol melalui Kokristalisasi dengan Koformer Asam Dipikolinat

Abstract

Paracetamol is one of the antipyretic and analgesic drugs indicated as pain and fever relievers. Paracetamol form I is often used in the pharmaceutical industry because it is thermodynamically stable at room temperature and pressure but has poor compactibility properties when compressed. Therefore, improvements are needed to make it easier to form into tablets with hardness and friability that meet the requirements. This study was conducted by forming paracetamol cocrystals with dipicolinic acid as the cofomer using the slow solvent evaporation method in a stoichiometric ratio of 1:1, and ethanol 98% as a solvent. This study aimed to improve the compactibility properties of paracetamol to form better tablets. Cocrystal formation was characterized by PXRD, FTIR, DSC, and SEM. The compactibility properties were evaluated by testing the tensile strength and elasticity recovery. The data obtained was analyzed using SPSS 26 for Windows to discover whether there were significant differences. The characterization results of paracetamol with dipicolinic acid coformer from slow solvent evaporation showed that cocrystals were formed. The results of the compactibility evaluation conducted, paracetamoldipicolinic acid cocrystals showed a greater TS value and a lower %ER value than paracetamol. The conclusion obtained from paracetamol cocrystals with dipicolinic acid coformer from slow solvent evaporation showed an improvement in compactibility properties compared to paracetamol.