| dc.description.abstract | Objective: To investigate the ability of a combination dental pulp mesenchymal stem cell secretome
(DPMSCS), robusta green coffee bean extract (RGCBE), and Carboxymethylcellulose-Natrium (CMC-Na) in
a Wistar rats model of traumatic ulcers. Material and Methods: Twenty-eight young, male, healthy Wistar
rats (Rattus norvegicus) were divided into seven groups randomly: Group K0, group K1-3 (traumatic ulcer rats
that received CMC-Na gel for three days), group K1-7 (traumatic ulcer rats that received CMC-Na gel for
seven days), group K2-3 (traumatic ulcer rats that received RGCBE for three days), group K2-7 (traumatic
ulcer rats that received RGCBE for seven days), group K3-3 (traumatic ulcer rats that received DPMSCS for
three days), and group K3-7 (traumatic ulcer rats that received DPMSCS for seven days). An ulcer was made
with an amalgam stopper on the right buccal mucosa of the rats. DPMSCS 50% gel was applied to the ulcer
on the left buccal mucosa. The ulcer diameter was measured on day 3 and day 7. Results: There was a
significant difference in the diameter of the ulcer, the number of neutrophils, and fibroblasts in the treatment
group compared to the control group on day 7. Conclusion: A combination of DPMSCS and RGCBE 50%
accelerates traumatic ulcer wound healing by lowering ulcer diameter, decreasing neutrophil counts, and
increasing fibroblast proliferation in vivo | en_US |
