| dc.description.abstract | t. Atorvastatin calcium is a potent active pharmaceutical ingredient that reduces blood
cholesterol levels. However, oral bioavailability is low because it is difficult to dissolve in water.
Therefore, further research to increase the solubility of the drug is needed to improve its
bioavailability properties. This research aimed to increase the solubility of atorvastatin calcium
through the formation of a multi-component solid. Furthermore, the drug was formed into a multi component solid with dipicolinic acid as a coformer using the solvent evaporation-quenching
method. A powder X-ray diffractometer (PXRD), Fourier transform infrared (FTIR) spectrometer,
differential scanning calorimeter (DSC), and scanning electron microscope (SEM) was used to
characterize the solid. Also, the shake-flask method was used to analyze the solubility of the solid in
distilled water. The results showed that atorvastatin calcium and dipicolinic acid formed a new
multi-component solid of cocrystal type. The solubility of the atorvastatin calcium from the multi component solid was 344.31 ± 37.09 mg/L, which was a significant increase of about 2.7-fold
compared to the pure form. | en_US |
