| dc.description.abstract | We conducted a systematic review research and meta-analysis to reveal the relationship between the risk of chronic diarrhea
and Cryptosporidium infection in people living with HIV in Southeast Asia. We performed online peer-reviewed literature
research from January 2005 to December 2017, which included PubMed, Science Direct, ProQuest, EBSCO, Cochrane, and
Web of Science databases. Calculation of size effects in the meta-analysis was performed by STATA 13.0 software to estimate
relative risks (RRs) with 95% confidence intervals (CIs) for any associations. Seven cross-sectional research articles were
recruited in this study based on the inclusion and exclusion criteria. Our analysis revealed a significant relationship between
cryptosporidiosis and the risk of chronic diarrhea in people living with HIV, with RR = 1.325; 95% CI = 1.157 to 1.517; and
P = .000. Our results suggested that cryptosporidiosis increases the risk of chronic diarrhea, and low CD4+ lymphocyte cell
counts aggravate the degree of diarrhea. Therefore, clinicians should be more aware in treating HIV-positive people, especially
those with low CD4+ cell counts, and we suggest that Cryptosporidium laboratory examinations be conducted immediately. | en_US |
