| dc.description.abstract | Atorvastatin calcium is a cholesterol-lowering drug that is very potent but difficult to dissolve in water, so its
bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid multicomponent solids were prepared using the
liquid-assisted grinding method to improve the solubility of atorvastatin calcium. Characterization of multicomponent solids
was carried out using powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), fourier transform infrared
spectroscopy (FTIR), and scanning electron microscopy (SEM). Solubility test was carried out by shaking method using
distilled water media. The results showed that the particles of atorvastatin calcium - dipicolinic acid multicomponent solids
had an irregular shape with rough and porous surface topography. The multicomponent solids have a diffractogram with
specific peaks of 2θ at 8.8, 9.9, 11.5, 16.7, 19.1, 21.2, 22.4, 23.4, and 27.7°. The DSC thermogram of multicomponent
solids showed a sharp endothermic peak at 181.9 °C (∆H=17.69 J/g), indicating its melting point. The FTIR spectra of
atorvastatin calcium-dipicolinic acid multicomponent solids indicated an intermolecular interaction that was thought to be
a hydrogen bond between the molecules of atorvastatin calcium and dipicolinic acid. The results of the solubility test
showed that the atorvastatin calcium-dipicolinic acid multicomponent solids had a significantly increased solubility
(p<0.05) compared to the solubility of pure atorvastatin calcium. | en_US |
