| dc.description.abstract | Atorvastatin calcium (AC) is a statin drug used to lower cholesterol. Its
crystalline form is usually found in the market with low solubility properties.
The amorphization of crystalline AC is a technique used to increase its
solubility however; the amorphous form has less thermodynamic stability.
Therefore, to increase the solubility properties of its crystalline form, an
AC coamorphous solid was prepared. This coamorphous solid was
prepared using spray drying techniques, and coformers such as
isonicotinamide (INA) and maleic acid (MA). Furthermore,
characterization was carried out using powder X-ray diffraction,
differential scanning calorimetry, fourier transform infrared spectroscopy,
and scanning electron microscopy, while the solubility properties test
was conducted using the shake-flask and paddle method. The results
showed that the spray-dried solids were coamorphous with single-phase
homogeneous systems. Furthermore, the coamorphous solids, AC-INA
and AC-MA were found to have a higher Tg than the melting points of
other components, and formed intermolecular interactions between
them. The higher Tg and presence of intermolecular interactions indicate
that coamorphous solids are more stable than the amorphous form.
Therefore, the results of the solubility and dissolution test showed that the
coamorphous solid of AC-INA and AC-MA have better solubility
properties compared to the AC crystalline form. | en_US |
