dc.contributor.author | WICAKSONO, Yudi | |
dc.contributor.author | SARI, Lusia Oktora Ruma Kumala | |
dc.contributor.author | ISTIQOMAH, Biru Putri Ayu | |
dc.contributor.author | AMALIYAH, Shofiatul Izzah Al | |
dc.contributor.author | SETYAWAN, Dwi | |
dc.date.accessioned | 2023-03-20T02:35:05Z | |
dc.date.available | 2023-03-20T02:35:05Z | |
dc.date.issued | 2022-04-29 | |
dc.identifier.uri | https://repository.unej.ac.id/xmlui/handle/123456789/113087 | |
dc.description.abstract | The objective of this study was to evaluate the analgesic activity and acute toxicity of the ketoprofennicotinamide multicomponent solid. The preparation of multicomponent solids was carried out by the solvent
evaporation method. The characterization of multicomponent solids was carried out by powder x-ray diffractometer
(PXRD), differential scanning calorimeter (DSC), and fourier transform infrared spectrometer (FTIR). Solubility
test was carried out by shaking method and evaluation of analgesic activity-toxicity was carried out in vivo in mice
strain BALB/c. The results showed that the ketoprofen-nicotinamide multicomponent solid formed a new solid
phase with different characteristics from the initial components. The ketoprofen-nicotinamide multicomponent
solid showed a significantly (p<0.05) increased solubility, which was 1.3 times compared to the solubility of pure
ketoprofen. In the evaluation of analgesic activity, the treatment group of multicomponent solid at a dose of 3.25
mg/kg body weight showed significantly increased pain inhibition (p<0.05) compared to the treatment group of
pure ketoprofen. The toxicity evaluation in experimental animals showed that the multicomponent solids did not
cause a significant (p>0.05) increase in SGOT and SGPT levels compared to the control group. Observations on
the stomach histology of experimental animals showed that the ketoprofen-nicotinamide multicomponent solid
gave a lighter infiltration of neutrophil inflammatory cells when compared to the pure ketoprofen group. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pharmaceutical Sciences Asia | en_US |
dc.subject | Acute toxicity | en_US |
dc.subject | Analgesic activity | en_US |
dc.subject | Ketoprofen | en_US |
dc.subject | Multicomponent solids | en_US |
dc.title | Evaluation of analgesic activity and acute toxicity of ketoprofen-nicotinamide multicomponent solids | en_US |
dc.type | Article | en_US |