| dc.description.abstract | Aluminum compounds can be easily found in the environment. Aluminum contamination is the
environmental factor as one of the risk factors for Alzheimer’s disease (AD). In the animal model, aluminum
chloride (AlCl3
) induces inflammation and oxidative stress. Inflammation and oxidative stress are important
pathogenesis pathways in the AD. This study was conducted to determine whether AlCl3
can impair
spatial memory and induce senile plaques formation. A total of 24 young adult Wistar rats were used in
this study. The rats were divided into four groups; one control group and three AlCl3
treated groups with
doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively for 8 weeks. The spatial memory test was
measured using Morris water maze and the histopathology was done by identification of senile plaques
formation in the hippocampal tissue. Statistical analysis was performed using one-way analysis of variance
(ANOVA) followed by Tukey’s test for multiple comparisons. The level of statistical significance was set
at a p value < 0.05. This study showed that there are significant differences (p<0,05) between the control
group and all the AlCl3
treatment groups in the memory test, however, there is no change in the senile
plaque’s expression in all groups. Administration of AlCl3
for 8 weeks can cause the impaired of spatial
memory without senile plaques formation. | en_US |
