| dc.description.abstract | Surgical site infection (SSI) in open fracture is often caused by bacterial contamination in the management of open
fracture. Because of that, one of the most important thing in handling open fracture is debridement. Prophylactic
antibiotics given are Cephalosporin and Aminoglycosides. Post-debridement culture is important in predicting the
incidence of infection. One of the bacteria that is often found in post-debridement culture is Klebsiella spp. which
can produce ESBL to fight β-lactam class of antibiotics. The purpose of this study was to determine antibiotic
sensitivity against Klebsiella spp. in the post-debridement culture of cases of open fractures in the emergency
department of dr. Soebandi hospital Jember. This study uses a laboratory exploratory research design. The sample
of this study was the isolate of Klebsiella spp. which amounts to 5 from post debridement culture of open fracture
patients in the emergency department of dr. Soebandi hospital Jember from March to May 2019.The method used
is diffusion (Kirby Baurer) by matching using the CLSI standard table to determine sensitive, intermediate, or
resistant. The results of this study showed that most antibiotics had resistance to Klebsiella spp., including βlactam antibiotics, such as Amoxicillin, Ceftriaxone, Cefixime, Penicilin, Meropenem, and Cefadroxil.
Vancomycin antibiotics are still sensitive to Klebsiella spp. in all patients. Gentamicin, Ciprofloxacin,
Tetracycline, and Chloramphenicol antibiotics were sensitive in 1 patient. Erythromycin intermediates antibiotics
against Klebsiella spp.. The conclusion of this study is that all β-lactam group antibiotics are resistant to Klebsiella
spp while the most sensitive antibiotic is Vancomycin. | en_US |
