| dc.description.abstract | Wound healing is a progressive physiological process with
overlapping stages. Hyperbaric oxygen therapy increases tissue
oxygenation, thereby increasing tissue oxygenation and the formation
of H2O2 as the second messenger of the phosphorylation of tumor
necrosis factor α, NOS, VEGF, and nuclear factor β-kappa. This
further study aims to determine whether hyperbaric oxygen therapy
can increase collagen 3, HSP 70, IL6 expression and wound healing.
This study is an animal study using "pre-test and post-test design of a
randomized control group". Divided into 4 groups (HBO 2.4 ATA 3x30
minutes, 10 sessions HBO 2.4 ATA 3x30 minutes, control group
without HBO), each group consisted of 7 groups with 28 male rats.
Excision of the wound 1x1cm was performed. The distribution of the
data was analyzed by SPSS. Hyperbaric oxygen therapy increased the
expression of Collagen 3 (p=0.04), HSP 70 (p=0.03), IL 6 (p=0.02) and
wound healing (p=0.002) with 5 sessions of HBO 2.4 ATA and 10
sessions of HBO 2.4 ATA increased Collage 3 (p=0.02), HSP 70
(p=0.04), L6 expression significantly (p=0.02) but did not significantly
improve wound healing (p=0, 3) compared without HBO. This study
was that HBO increased the expression of Collagen 3, HSP 70, IL 6
and wound healing in 5 sessions of HBO 2,4 ATA 3x30 minutes. | en_US |
