Show simple item record

dc.contributor.authorSETIAWATIE, Ernie Maduratna
dc.contributor.authorGANI, Maria Apriliani
dc.contributor.authorRAHAYU, Retno Puji
dc.contributor.authorULFA, Noer
dc.contributor.authorKURNIA, Shafira
dc.contributor.authorAGUSTINA, Eka Fitria
dc.contributor.authorSARI, Desi Sandra
dc.date.accessioned2022-05-11T06:45:38Z
dc.date.available2022-05-11T06:45:38Z
dc.date.issued2022-05-09
dc.identifier.govdocKODEPRODI1610101#Kedokteran Gigi
dc.identifier.govdocNIDN0015127804
dc.identifier.urihttp://repository.unej.ac.id/xmlui/handle/123456789/106718
dc.description.abstractObjective: Periodontitis is an infectious disease that results in gingiva tissue damage. This study aimed to evaluate the effects of Nigella sativa (N. sativa) toothpaste in a periodontitis tissue repair based on inflammation and periodontal extracellular matrix in vivo. Design: The periodontitis disease model was developed using Wistar rats infected with Porphyromonas gingivalis (P. gingivalis). The rats were divided into three main groups as follows: those that did not receive any toothpaste treatment; those that were treated with N. sativa toothpaste twice a day (simultaneously with P. gingivalis induction); and normal healthy rats. The rats were sacrificed after 1 and 7 days of animal modeling. The number of inflammatory cells, matrix metalloproteinase (MMP)1 + and MMP8 + cells, levels of cytokines (interleukin-1β (IL-1β) and prostaglandin E2 (PGE2)) and density of collagen type 1 were determined in the gingival tissues of the rats. Results: The rats treated with N. sativa toothpaste had significantly lower numbers of neutrophils, macrophages and lymphocytes than the non-treated rats after 1 and 7 days of treatment; likewise, the levels of IL-1β and PGE2 were lower in the treated experimental rats. In addition, the group treated with N. sativa toothpaste had fewer numbers of MMP1 + and MMP8 + cells and higher collagen density after 1 and 7 days of administration. Conclusions: N. sativa toothpaste exhibited anti-inflammatory effects by reducing both inflammatory cell count and activity. Additionally, N. sativa toothpaste demonstrated anti-destructive effects on the periodontal extracellular matrix. Thus, N. sativa toothpaste might be potentially used for the management of periodontitis.en_US
dc.language.isoenen_US
dc.publisherArchives of Oral Biologyen_US
dc.subjectBlack cuminen_US
dc.subjectAntibacterial toothpasteen_US
dc.subjectDental plaqueen_US
dc.subjectPorphyromonas gingivalisen_US
dc.subjectInfectious diseaseen_US
dc.titleNigella sativa toothpaste promotes anti-inflammatory and anti-destructive effects in a rat model of periodontitisen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record