| dc.description.abstract | Fever is one of the body's physiological responses to metabolic stress, characterised
by increasing body temperature. Based on its phytochemical content, Bandotan (tropical
whiteweed) is an alternative antipyretic therapeutic agent. Flavonoids are potential chemical
contents that can be extracted with various solvents, including ethanol and ethyl acetate. So far,
research on its antipyretic potential is limited. Aim: To compare the antipyretic activity of
ethanol extract to ethyl acetate extract of Bandotan herb in hyperpyrexia mice. Methods:
Bandotan herb extracts were prepared by maceration, followed by phytochemical screening and
determining total flavonoid content. Hyperpyrexia mice were made by induction of baker's yeast.
Four hours after injection, mice were treated with Bandotan herb extracts, a dose of 100, 200,
and 400 mg/kg body weight (BW), then the rectal temperature was observed for four hours.
Results: Both extracts contained flavonoid, alkaloid, saponin, tannin, and steroid, while terpenoid
was only found in ethanol preparation. The total flavonoid content of ethyl acetate extract was
higher than that of ethanol extract. The best antipyretic activity was a dose of 400 mg/kg BW, but
there was no significant difference in the percentage of pyrexia inhibition. Conclusion: Both
extracts have the same ability to be developed as an alternative antipyretic agent. | en_US |
