Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica
Date
2022-01-05Author
NUGRAHA, Satia
PURNOMO, Yoshinta Debby
PRATAMA, Antonius Nugraha Widhi
TRIATMOKO, Bawon
HENDRA, Rudi
WONGSO, Hendris
AVERY, Vicky
KELLER, Paul A.
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Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial
lead compounds to combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into the
Indonesian medicinal plants Swietenia mahagoni and Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated
34,5-tri-O-caffeoylquinic acid (4) to be the most active against Plasmodium falciparum 3D7 and Dd2 strains with IC50 values of 8.2 and
8.8 µM, respectively. No cytotoxicity was observed against Human Embryonic Kidney cells at a concentration of 40 µM.
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- LSP-Jurnal Ilmiah Dosen [7292]