| dc.description.abstract | Gotu Kola (Centella asiatica L.), known as pegagan is a plant with many benefits,
including used to repair burns, hypertrophic wound healing, and as an inflammatory agent. C.
asiatica grows in tropical Asia and grows in various countries such as Indonesia, Philippines,
China, India, Sri Lanka, and Madagascar. C. asiatica has four bioactive components, namely
asiatic acid, asiaticoside, madecassic acid, and madecassoside. Microwave-Assisted Extraction
(MAE) is one of the methods for extracting bioactive compounds of pegagan leaf. In this study,
the extraction of pegagan bioactive compounds carried out using the Solvent-Free MicrowaveAssisted Extraction (SFME) method. This research used a box-behnken design model for the
optimization process. The variables used are mass of material (20, 40, 60 g), power (150, 300,
450 W), and time of extraction (30, 60, 90 min). The highest yield is 4,5474% at 450 watt
microwave power, 20 g mass pegagan leaves, and 60 min extraction time. Mass of material is
the factor that has significant effect on yield. Modelling from this research is appropriate which
has lack-of-fit > 0,1, and R2 89,67%. The content of bioactive compounds carried out by
analyzing the total phenolic content of the product. The most substantial phenol content is
2398,649 μgAGE/ml. | en_US |
