| dc.description.abstract | Bitter melon seed oil has an antioxidant activity which is beneficial to
treat various degenerative diseases. However, the bitter melon seed oil is less
soluble in the gastrointestinal tract and has low absorption. Therefore, a selfnanoemulsion dosage form is needed to support its absorption and maintain
its antioxidant activity. This study aimed to formulate bitter melon seed oil
into a self-nano emulsifying drug delivery system (SNEDDS) and examine its
antioxidant activity change after being transformed into SNEDDS using the
Ferric Reducing Antioxidant Power (FRAP) method and DPPH (2,2-diphenyl1-picrylhydrazyl) assay. The SNEDDS formulation uses bitter melon seed oil
as the active ingredient and the oil phase, Cremophor RH 40 as a surfactant,
and glycerin as a co-surfactant. The results showed that the best SNEDDS
formula has a ratio of oil: Smix (surfactants mixture) of 1:4. The best formula
transmittance was 97.35±0.04% with an emulsification time of 15.69±0.06
seconds, a pH value of 6.87±0.08, and a particle size of 31.8±16.3nm.
Thermodynamic stability and robustness to dilution tests showed that the
preparation was stable and resistant to various dilutions and pH. The
antioxidant activity of bitter melon seed oil before and after being
transformed into SNEDDS resulted in a statistically insignificant difference.
This study concluded that bitter melon seed oil SNEDDS has good physical
characteristics, stability, and no antioxidant activity changes after
formulation, supporting its application to new therapeutic uses | en_US |
