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dc.contributor.authorAMANULLAH, Adiz Dwiputra Rahmadhan
dc.contributor.authorARMIYANTI, Yunita
dc.contributor.authorHERMANSYAH, Bagus
dc.contributor.authorHELIANTI, Dina
dc.contributor.authorNURDIAN, Yudha
dc.date.accessioned2022-02-03T05:52:27Z
dc.date.available2022-02-03T05:52:27Z
dc.date.issued2021-01-01
dc.identifier.govdocKODEPRODI2010101#Pendidikan Dokter
dc.identifier.govdocNIDN0004067405
dc.identifier.govdocNIDN0005048306
dc.identifier.govdocNIDN0004117406
dc.identifier.govdocNIDN 0019107103
dc.identifier.urihttp://repository.unej.ac.id/xmlui/handle/123456789/105681
dc.description.abstractAscaris lumbricoides is nematode which often infest human in the world. The infestation of A. lumbricoides in the human will trigger the formation of Th2 immune responses through increased interleukin-4 released by innate immune cells. Th2 immune response generates B lymphocyte cells to produce IgE antibodies to eliminate A. lumbricoides. Therefore, IL-4 is a marker of Th2 immune response. The purpose of this study was to determine the prevalence of ascariasis and an increase of IL-4 in planters infested with A. lumbricoides as a marker of Th2 immune response. Our study was observational analytic with cross sectional design. 230 planters who were willing to be involved in the study gave stool samples for the diagnosis of ascariasis. 20 people who were positive for ascariasis and 20 people who were negative selected randomly for blood plasma samples. IL-4 levels in blood plasma were measured using ELISA. Differences in IL4 levels between positive and negative ascariasis were analyzed by the Mann Whitney statistical test with p value ≤ 0.05. The prevalence of ascariasis among planters in rural area of Jember was 16,52% which was included low prevalence. Univariate analysis showed that the mean and median levels of IL-4 ascariasis were greater than those of healthy planters. Mann Whitney test results showed that there were differences in levels of IL-4 between ascariasis and healthy planters (p≤0.05). Increased levels of IL-4 in planters with ascariasis indicate that A. lumbricoides infection triggers the formation of Th2 immune response as a mechanism for eliminating A. lumbricoides.en_US
dc.publisherJurnal ILMU DASARen_US
dc.subject: Interleukin-4en_US
dc.subjectA. lumbricoidesen_US
dc.subjectTh2 immune responseen_US
dc.titlePeningkatan Interleukin-4 Pada Pekebun dengan Askariasis di Wilayah Rural Jemberen_US
dc.typeArticleen_US


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