Identification of Coronary Atherosclerotic Lesions in Rat Induced by Intravenous Candida Albicans
Date
2018-08-01Author
PRASETIYA, Rendra Chriestedy
FATIMATUZZAHRO, Nadie
SUSILAWATI, I Dewa Ayu
YONENDA, Ayu prativia
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Objective: This study aimed to identify the sign of coronary atherosclerosis lesion in rat induced by intravenous Candida albicans.
Methods: This research was an experimental laboratories (in vivo) that used 15 male Wistar rat, divided into three groups of the control, the first
treatment group injected by C. albicans intravenously with concentration of the 10−10 cells/mL and the second treatment group injected by C. albicans
intravenously with concentration of the 10−12 cells/mL. 0.2 mL of C. albicans were injected to the first and second treatment group on 1st, 4th, 9th,
16th, and 23rd day. On the 5th week, rats were sacrificed, taken its hearts that contained the coronary artery. Rat’s heart had been fixed; histological
preparations were made and painted with Picrosirius Red and Sudan IV, observed by a microscope.
Results: The artery walls of the first and second treatment group were thicker than the control group. Lesions and disposition lipids of the first and
second treatment group were more frequent than the control group.
Conclusion: Intravenous C. albicans can increase the risk of coronary atherosclerosis
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- LSP-Jurnal Ilmiah Dosen [7292]