Pengaruh Ekstrak Kayu Manis (Cinnamomum Burmannii) terhadap Gambaran Histopatologi Hepar Tikus Model Diabetes Melitus

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia that contributes to increased oxidative stress, leading to structural and functional liver damage.Excessive production of reactive oxygen species (ROS) in DM induces lipid peroxidation, mitochondrial dysfunction, activation of the apoptototic pathways, and inflammatory responses, thereby exacerbating the severity of hepatic injury. Therefore, the use of natural compounds with antidiabetic and antioxidant properties represents a promising therapeutic approach to provide hepatoprotective effects and prevent the progression of liver damage in DM. This study aimed to evaluate the effect of Cinnamomum burmannii extract on the severity of liver histopathological damage in a diabetic rat model. This experimental study employed a post-test only control group design using male Wistar rats induced with diabetes through intraperitoneal injection of streptozotocin (STZ) at a dose of 40 mg/kgBW. The rats were divided into four groups: normal control (K-), positive diabetic control (K+), and two treatment groups (P1 and P2) receiving Cinnamomum burmannii extract at different doses. Liver damage was assessed through histopathological examination using the Manja-Roenigk scoring system. The results showed that the diabetic rat model in the K+ group experienced more severe histopathological liver damage, characterized by hepatocyte degeneration, cytoplasmic vacuolization, central vein congestion, and necrosis. In contrast, administration of Cinnamomum burmannii extract in the treatment groups significantly reduced the severity of hepatocellular damage. Statistical analysis using the One Way ANOVA showed a significant difference among groups (p≤0,001), which was further confirmed by the Post Hoc LSD test showing significant differences between the positive control group and the treatment group. These findings indicate that Cinnamomum burmannii extract has the potential to reduce the severity of liver damage in diabetes mellitus.