Optimasi Temperatur dan Durasi Pregelatinasi Pati Umbi Talas Kimpul (Xanthosoma Sagittifolium)
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FAKULTAS FARMASI
Abstract
Research was conducted to modify kimpul taro starch (Xanthosoma
sagittifolium) so that it can improve the flowability and good compressibility of
kimpul taro starch as a binding and filler excipient because natural starch has
shortcomings, namely poor flowability and compressibility. Modification of natural
starch can be done by pregelatination to improve flow properties and
compressibility because in this modification the heating process can cause water to
enter the particles so that it can increase the size and shape of the particles. Factorial
design was used to predict the optimum conditions of pregelatinized kimpul taro
starch with responses used to see the effect of modifications, namely flow time,
angle of repose, moisture content, Carr's index, and Hausner ratio. The optimal
conditions obtained from analysis using a factorial design are that the
pregelatination temperature used is 70o C and the pregelatination duration used is
30 minutes with a desirability value of 0.684. The response predicted by the
optimum conditions is as follows: flow time 6.213 g/second, Hausner ratio 1.123,
moisture content 11.093%, Carr's index 11.333%, and loss at rest of 35.356o. The
optimized pregelatinized taro starch showed desirable characteristics, such as better
flow properties and compressibility index when compared with natural starch. The
conclusion of this research can be said that the research succeeded in optimizing
the pregelatinization process of kimpul taro starch to produce powder with the
desired properties, so that it can be used in pharmaceutical formulations as a binder
and filler.
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Reuploud Repository hasyim Juni 2026
