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dc.contributor.authorKusumawardani, Banun
dc.contributor.authorSoesatyo, Marsetyawan HNE
dc.contributor.authorDasuki, Djaswadi
dc.contributor.authorAsmara, Widya
dc.date.accessioned2014-01-07T06:42:03Z
dc.date.available2014-01-07T06:42:03Z
dc.date.issued2013-09-06
dc.identifier.isbn9789792599220
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/13842
dc.description.abstractBackground: Periodontal infection caused by Gram-negative anaerobic organisms can act as a potential threat in the feto-placental unit. The placenta forms a barrier against the maternal immune system. This study aimed to analyze the effect of periodontal disease on TNF-α expression in the rat placental cells. Methods: Female rats were infected with live-Porphyromonas gingivalis at concentration of 2x109 cells/ml into subgingival sulcus area of the maxillary first molar before and/or during pregnancy. They were sacrificed on gestational day 14 and 20. The expression of TNF-α in trophoblast cells was detected by immunohistochemistry. Results: TNF-α expressions of the control, Pg-BD, Pg-B and Pg-D groups were significantly different (P<0.05) in syncytiotrophoblasts, trophoblastic giant cells and spongiotrophoblasts on GD14, while on GD 20 TNF-α expressions were significantly different only in syncytiotrophoblasts and trophoblastic giant cells on GD 20. Conclusion: The role of TNF-α in the control group is thought to be involved in the early growth of the fetus. A little expression of TNF-α can be beneficial for pregnancy, while increased expression of TNF-α is very adverse. Initial implantation and a successful pregnancy depend on the tight regulation of the TNF-α expression in placental tissue.en_US
dc.publisherFKG Unpaden_US
dc.relation.ispartofseriesProsiding Temu Ilmiah Forum Dies 54;
dc.subjectperiodontal diseaseen_US
dc.subjectpregnancyen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjectplacental tissueen_US
dc.titleEffect of Maternal Periodontal Disease on Tumor Necrosis Factor-alpha Expression in the Rat Placental Cellsen_US
dc.typeArticleen_US


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