Efektivitas Ekstrak Daun Mangga Var. Kuini (Mangifera Odorata Griff.) Terhadap Penurunan Kadar Glukosa Darah pada Mencit Putih Jantan Hiperglikemia dan Pemanfaatannya sebagai Book Chapter

Abstract

Diabetes mellitus is a chronic disease characterized by hyperglycemia. The continuous use of synthetic drugs often leads to long-term side effects, necessitating the use of natural remedies derived from organic materials as alternatives. This study aims to identify the flavonoid compound content, analyze the most optimal dosage to reduce blood glucose levels in hyperglycemic mice, and evaluate the feasibility of a book chapter as a learning resource. This experimental laboratory research utilized a Completely Randomized Design (CRD) on 42 male BALB/c strain mice divided into 6 treatment groups: normal control, negative control, positive control, and three dosage groups of kuini mango (Mangifera odorata) leaf extract (100mg/kgBW, 200mg/kgBW, and 300mg/kgBW). The extraction method employed was Soxhlet extraction using 70% ethanol as a solvent. The collected data were then analyzed using SPSS through ANOVA and Duncan's post-hoc tests. Phytochemical screening revealed that the kuini mango leaf extract positively contained flavonoid compounds. Data analysis demonstrated that the administration of kuini mango leaf extract for 14 days was effective in significantly reducing blood glucose levels. The most optimal dosage of the extract in lowering blood glucose levels was 100mg/kgBW, with an average blood glucose reduction of 50,25 mg/dL. This result was slightly more effective than the positive control group treated with glibenclamide. Kuini mango leaf extract is effective in reducing blood glucose levels, with 100mg/kgBW being the optimal dosage. The resulting book chapter is declared feasible for use as an educational tool and reading material for the public.