COCRYSTAL OF ATORVASTATIN CALCIUM – MALONIC ACID
Siswoyo, Tri Agus
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Cocrystal is a relatively new solid form of active pharmaceutical ingredient that offers an alternative platform in improving physicochemical properties of active pharmaceutical ingredients Padrela et al., 2009; Mashhadi et al., 2004. Cocrystal is defined as a stoichiometric multi-component system connected by non-covalent interactions where all the components neutral and solid under ambient conditions Thakuria et al., 2013. Cocrystal can be constructed through interaction hydrogen bonding, pi-stacking, and van der Waals forces Mashhadi et al., 2004. A pharmaceutical cocrystal is composed of an API and an appropriate coformer as carboxylic acids and amides Qiao et al., 2011. Cocrystallization of active pharmaceutical ingredient is an opportunity for enhancement of important physiochemical properties of an active pharmaceutical ingredient without changing its molecular structure Maeno et al., 2014.