| dc.description.abstract | Cocrystal is a relatively new solid form of active
pharmaceutical ingredient that offers an alternative
platform in improving physicochemical properties of
active pharmaceutical ingredients Padrela et al.,
2009; Mashhadi et al., 2004. Cocrystal is defined as
a stoichiometric multi-component system connected
by non-covalent interactions where all the
components neutral and solid under ambient
conditions Thakuria et al., 2013. Cocrystal can be
constructed through interaction hydrogen bonding,
pi-stacking, and van der Waals forces Mashhadi et
al., 2004. A pharmaceutical cocrystal is composed of
an API and an appropriate coformer as carboxylic
acids and amides Qiao et al., 2011.
Cocrystallization of active pharmaceutical ingredient
is an opportunity for enhancement of important
physiochemical properties of an active
pharmaceutical ingredient without changing its
molecular structure Maeno et al., 2014. | en_US |
