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    Anti-Cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: Physcia Millegrana, Parmelia Dilatata and Parmelia Aurulenta

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    Date
    2020-10-01
    Author
    NUGRAHA, Ari Satia
    LAKSONO, Tinton Agung
    FIRLI, Lilla Nur
    PUTRI, Chintya Permata Zahky Sukrisno
    PRATOKO, Dwi Koko
    ZULFIKAR, Zulfikar
    UNTARI, Ludmilla Fitri
    WONGSO, Hendris
    LAMBERT, Jacob M.
    DILLON, Carolyn T.
    KELLER, Paul A.
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    Abstract
    Cancer is a serious health burden on global societies. The discovery and development of new anti-cancer therapies remains a challenging objective. Although it has been shown that lichen secondary metabolites may be potent sources for new anti-cancer agents, the Indonesian- grown folious lichens, Physcia millegrana, Parmelia dilatata and Parmeila aurulenta, have not yet been explored. In this study exhaustive preparative high-performance liquid chromatography was employed to isolate the lichen constituents with spectroscopic and spectrometric protocols identifying nine depsides 9–17, including the new methyl 4-formyl-2,3-dihydroxy-6-methylbenzoate 13. The cytotoxicity of the depsides towards cancer cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated lowest toxicity of the depsides towards human A549 lung cancer cells. Importantly, the di-depsides (11, 12 and 17) showed greatest toxicity, indicating that these structures are biologically more active than the mono-depsides against the HepG2 liver cancer, A549 lung cancer and HL-60 leukemia cell lines.
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    http://repository.unej.ac.id/handle/123456789/104683
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    • LSP-Jurnal Ilmiah Dosen [7410]

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    UPA-TIK Copyright © 2024  Library University of Jember
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    Indonesia DSpace Group :

    University of Jember Repository
    IPB University Scientific Repository
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