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dc.contributor.authorNUGRAHA, Ari Satia
dc.contributor.authorLAKSONO, Tinton Agung
dc.contributor.authorFIRLI, Lilla Nur
dc.contributor.authorPUTRI, Chintya Permata Zahky Sukrisno
dc.contributor.authorPRATOKO, Dwi Koko
dc.contributor.authorZULFIKAR, Zulfikar
dc.contributor.authorUNTARI, Ludmilla Fitri
dc.contributor.authorWONGSO, Hendris
dc.contributor.authorLAMBERT, Jacob M.
dc.contributor.authorDILLON, Carolyn T.
dc.contributor.authorKELLER, Paul A.
dc.date.accessioned2021-05-20T03:30:08Z
dc.date.available2021-05-20T03:30:08Z
dc.date.issued2020-10-01
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/104683
dc.description.abstractCancer is a serious health burden on global societies. The discovery and development of new anti-cancer therapies remains a challenging objective. Although it has been shown that lichen secondary metabolites may be potent sources for new anti-cancer agents, the Indonesian- grown folious lichens, Physcia millegrana, Parmelia dilatata and Parmeila aurulenta, have not yet been explored. In this study exhaustive preparative high-performance liquid chromatography was employed to isolate the lichen constituents with spectroscopic and spectrometric protocols identifying nine depsides 9–17, including the new methyl 4-formyl-2,3-dihydroxy-6-methylbenzoate 13. The cytotoxicity of the depsides towards cancer cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated lowest toxicity of the depsides towards human A549 lung cancer cells. Importantly, the di-depsides (11, 12 and 17) showed greatest toxicity, indicating that these structures are biologically more active than the mono-depsides against the HepG2 liver cancer, A549 lung cancer and HL-60 leukemia cell lines.en_US
dc.language.isoenen_US
dc.publisherBiomoleculesen_US
dc.subjectIndonesiaen_US
dc.subjectlichenen_US
dc.subjectPhyscia millegranaen_US
dc.subjectParmelia dilatataen_US
dc.subjectParmelia aurulentaen_US
dc.subjectdepsidesen_US
dc.subjectanti-canceren_US
dc.titleAnti-Cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: Physcia millegrana, Parmelia dilatata and Parmelia aurulentaen_US
dc.typeArticleen_US
dc.identifier.kodeprodiKODEPRODI2210101#Farmasi
dc.identifier.nidnNIDN0021077803
dc.identifier.nidnNIDN0012106308
dc.identifier.nidnNIDN0028048502


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