SINTESIS 1-(3,4-DIKLOROBENZOILOKSIMETIL)-5FLUOROURASIL SEBAGAI PENGEMBANGAN OBAT KANKER

Abstract

ABSTRACT 5-fluorouracil is an antineoplastic agent as an antimetabolite that used for treating breast, colorectal and gastric cancers. Several compound as a derivative 5 fluorouracil has been synthesis for increase its activity and reduce side effect. 1-(3,4-dichlorobenzoyloximetil)-5 fluorouracil is a derivative of 5 fluorouracil that synthesized for development drugs. Synthesis 1-(3,4dichlorobenzoyloxymethyl)-5 fluorouracil has two step. The first step is alkylation

between 5-fluorouracil and formaldehyde to produce 1-hydroxymethyl-5fluorouracil. The second step is benzoylation between 1-hydroxymethyl-5fluorouracil and 3,4-dichlorobenzoylchloride to give the target compound, 1(3,4-dichlorobenzoyloxymethyl)-5-fluorouracil. This

compound has been purified

by

Column

Chromatography and give white color with melting point 184-186 C and then fix identification by H-NMR 500 MHz and KBr FTIR. 1-(3,4dichlorobenzoyloxy methyl)-5-fluorouracil probably can synthesed and resuted ±9,27 % of yield and its unstability that caused still have degradan 3,4dichlorobenzoic acid.