SINTESIS 1-(4-TRIFLUOROMETILBENZOILOKSIMETIL)-5- FLUOROURASIL SEBAGAI UPAYA PENGEMBANGAN OBAT ANTIKANKER

Abstract

ABSTRACT 5-fluorouracil is an antimetabolite class of anticancer agents that work induces apoptosis by inhibiting thymidilic acid biosynthesis. A novel 5-fluorouracil derivatives, 1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil were synthesized by two steps reaction. The first step is alkylation reaction between 5-fluorouracil, formaldehyde and aquadest to produce 1-hidroxymethyl-5-fluorouracil. The second step is benzoylation reaction between 1-hidroxymethyl-5-fluorouracil and 4- trifluoromethylbenzoylchloride for 11 hours to produce the target compound. Target compound purified by column chromatography. Purified compound characterized and identified by 1HNMR and FTIR KBr. Product compound form white needles crystal with melting range 172-174oC. Spectra of 1HNMR and FTIR KBr showed that pure 1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil was successfully synthesized.