Sintesis 1-(3,4-Diklorobenzoiloksimetil)-5- Fluorourasil sebagai Pengembangan Obat Kanker

Abstract

ABSTRACT 5-fluorouracil is an antineoplastic agent as an antimetabolite that used for treating breast, colorectal and gastric cancers. Several compound as a derivative 5 fluorouracil has been synthesis for increase its activity and reduce side effect. 1-(3,4-dichlorobenzoyloximetil)-5 fluorouracil is a derivative of 5 fluorouracil that synthesized for development drugs. Synthesis 1-(3,4- dichlorobenzoyloxymethyl)-5 fluorouracil has two step. The first step is alkylation between 5-fluorouracil and formaldehyde to produce 1-hydroxymethyl-5- fluorouracil. The second step is benzoylation between 1-hydroxymethyl-5- fluorouracil and 3,4-dichlorobenzoylchloride to give the target compound, 1- (3,4-dichlorobenzoyloxymethyl)-5-fluorouracil. This compound has been purified by Column Chromatography and give white color with melting point 184-186oC and then fix identification by H-NMR 500 MHz and KBr FTIR. 1-(3,4- dichlorobenzoyloxy methyl)-5-fluorouracil probably can synthesed and resuted ±9,27 % of yield and its unstability that caused still have degradan 3,4- dichlorobenzoic acid.