| dc.description.abstract | Diabetes mellitus (DM) occur when human body is unable to produce enough insulin and/or
unable to use insulin effectively, resulting in an increase of blood sugar levels (hyperglycemia).
Indonesia has ranks fourth after United States, China and India in the prevalence of DM.
Controling blood sugar and insulin levels can be done through the stimulation effect of Glucagonlike
peptide-1
(GLP-1).
The
goal
of
this
study
was
to
determine
the
effects
of
resistant
starch
type
3
(RS3) from cassava starch in increasing plasma GLP-1 levels. This reasearch use male mouse
(Ratttus novergicus) as a diabetic model by providing a high-fat diet (HFD) for one mounth than
combine with intraoperitonel injection of low dose streptozotocin (STZ). The mouse then grouped
into 4 groups randomly (1) normal or negative control, (2) cassava starch diet, (3) RS3 diet, (4)
positive control. Blood sugar levels were measured before and after STZ injection to determine the
diabetic conditions (blood sugar > 200 mg /dL). After 4 weeks of dietary administration blood
sugar and plasma GLP-1 levels were examined using ELISSA. Statistical analysis showed
decreased in blood sugar levels and increased in plasma GLP-1 levels after one mounth of RS3
diet. This research shows that RS3 from cassava starch has a potential role as a nutritional therapy
on diabetes mellitus condition. | en_US |
