OPTIMASI KOMPOSISI HIDROKSIPROPIL METILSELULOSA, NATRIUM ALGINAT DAN NATRIUM KARBOKSIMETILSELULOSA PADA TABLET PROPRANOLOL HIDROKLORIDA SISTEM MENGAPUNG DAN LEKAT MUKOSA

Abstract

A combination floating and mucoadhesive drug delivery system of propranolol hydrochloride tablet has been developed to increase its bioavailability by increasing the retention time of the drug in the gastrointestinal tract. The aim of this study was to formulated, optimized, and obtained the optimal composition of Hidroxypropyl Methylcellulose